A comprehensive survey of scoring functions for protein docking models

A comprehensive survey of scoring functions for protein docking models

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Abstract Background While protein-protein docking is fundamental to our understanding of how proteins interact, scoring protein-protein complex conformations is a critical component of successful docking programs.Without accurate and efficient scoring functions to differentiate between native and non-native binding complexes, the accuracy of current docking stickers logos dallas cowboys tools cannot be guaranteed.Although many innovative scoring functions have been proposed, a good scoring function for docking remains elusive.Deep learning models offer alternatives to using explicit empirical or mathematical functions for scoring protein-protein complexes.

Results In this study, we perform a comprehensive survey of the state-of-the-art scoring functions by considering the most popular and highly performant approaches, both classical and deep learning-based, for scoring protein-protein complexes.The methods were also compared based on their runtime as it directly impacts their use in large-scale docking applications.Conclusions We beer button down shirts for men evaluate the strengths and weaknesses of classical and deep learning-based approaches across seven public and popular datasets to aid researchers in understanding the progress made in this field.